Original Article Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia John J.P. Kastelein, M.D., Ph.D., Fatima Akdim, M.D., Erik S.G. Stroes, M.D., Ph.D., Aeilko H.
Zwinderman, Ph.D., Michiel L. Bots, M.D., Ph.D., Anton F.H. Stalenhoef, M.D., Ph.D., F.R.C.P., Frank L.J. Visseren, M.D., Ph.D., Eric J.G. Sijbrands, M.D., Ph.D., Mieke D. Trip, M.D., Ph.D., Evan A. Stein, M.D., Ph.D., Daniel Gaudet, M.D., Ph.D., Raphael Duivenvoorden, M.D., Enrico P.
Local Radio - Local Issues - Local Presenters - Proud to be at the Heart of your Community. Click the station. Conflict: Readings in. Management and. Edited by John Burton and Frank Dukes. Center for Conflict Analysis and Resolution, George Mason University. Virginia, USA. The term prevention has the connotation of containment. Michael Banks is a Reader in International Relations at the London.
Conflict Resolution And Prevention John Burton Pdf Readers
Veltri, M.D., A. David Marais, M.D., Ph.D., and Eric de Groot, M.D., Ph.D., for the ENHANCE Investigators N Engl J Med 2008; 358:1431-1443 DOI: 10.1056/NEJMoa0800742. Methods We conducted a double-blind, randomized, 24-month trial comparing the effects of daily therapy with 80 mg of simvastatin either with placebo or with 10 mg of ezetimibe in 720 patients with familial hypercholesterolemia.
Patients underwent B-mode ultrasonography to assess the intima–media thickness of the walls of the carotid and femoral arteries. The primary outcome measure was the change in the mean carotid-artery intima–media thickness, which was defined as the average of the means of the far-wall intima–media thickness of the right and left common carotid arteries, carotid bulbs, and internal carotid arteries. Results The primary outcome, the mean (±SE) change in the carotid-artery intima–media thickness, was 0.0058±0.0037 mm in the simvastatin-only group and 0.0111±0.0038 mm in the simvastatin-plus-ezetimibe (combined-therapy) group (P=0.29). Secondary outcomes (consisting of other variables regarding the intima–media thickness of the carotid and femoral arteries) did not differ significantly between the two groups. At the end of the study, the mean (±SD) LDL cholesterol level was 192.7±60.3 mg per deciliter (4.98±1.56 mmol per liter) in the simvastatin group and 141.3±52.6 mg per deciliter (3.65±1.36 mmol per liter) in the combined-therapy group (a between-group difference of 16.5%, P. Figure 2 Effects of Simvastatin and Combined Therapy with Simvastatin plus Ezetimibe on Levels of Cholesterol and Triglycerides. All measures of cholesterol — low-density lipoprotein (LDL) cholesterol (Panel A), high-density lipoprotein (HDL) cholesterol (Panel B), and total cholesterol (Panel C) — were calculated with the use of analysis for variance for each time point.
The I bars represent standard errors. An analysis for covariance on rank-transformed data for each time point was used for the triglyceride curve (Panel D). A reduction in levels of low-density lipoprotein (LDL) cholesterol constitutes one of the cornerstones in the prevention of cardiovascular disease. Beyblade metal fusion theme song in hindi free download. In recent trials comparing various statins or the same statin at various doses, aggressive therapy to lower LDL cholesterol levels was associated with a reduction in rates of cardiovascular events.